![]() ![]() ![]() We characterized serological antibody repertoires against 344,000 peptides using PhIP-seq libraries from a wide range of microbial and environmental antigens in 1,443 participants from a population cohort. In this study, we investigated the effects of genetic, environmental, and intrinsic factors on the variation in human antibody repertoires. However, a comprehensive overview of environmental and genetic determinants shaping human adaptive immunity is lacking. Electronic address: immunoprecipitation sequencing (PhIP-seq) has enabled high-throughput profiling of human antibody repertoires. 9 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.Electronic address: 1 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 8 Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.7 Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.6 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.5 Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.Electronic address: 4 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 3 Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine, Medical University Graz, Graz, Austria Center for Cancer Research, Medical University of Vienna, Wien, Austria.2 Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.1 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. ![]()
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